個人簡介
理學博士。1969年1月生。bat365官网登录特聘教授，蘇州絲美特生物技術有限公司創始人兼首席科學家，美國Tufts 大學生物醫學系助理教授，蘇州工業園區納米領軍人才、姑蘇領軍人才。現任職bat365官网登录bat365官网登录及現代絲綢國家工程實驗室，創建了bat365官网登录-Tufts大學生物醫用材料聯合實驗室。主要研究天然絲素蛋白生物材料的工業化制備及其在組織工程修複、藥物遞送、生物3D打印、生物傳感器和日用品工業中的應用。正在主持國家自然科學基金中德科技合作項目、國家自然科學基金面上項目和工業橫向項目。王曉沁于1991年獲得山東大學微生物工程專業學士學位，1998年獲得北京協和醫科大學分子生物學碩士學位，2004年獲得荷蘭格羅甯根（Groningen）大學博士學位。曾先後任職荷蘭貝爾美德（BioMaDe）生物技術公司、美國塔夫茨（Tufts）大學生物醫學系、美國ETEX生物技術公司、美國Ekteino Laboratory, Cocoon Biotech等生物技術公司，擔任新産品和新技術研發負責人。
研究方向及主講課程
主要研究方向：絲素蛋白基藥物緩釋及組織修複；功能化絲素蛋白生物材料
近五年主持的科研項目
1. 國家重點研發計劃“生物醫用材料研發及組織器官修複替代” （項目參與） 2017-2021
2. 國家自然科學基金中德合作項目：有效利用巨噬細胞可塑性促進骨再生 （項目主持） 2015年至今
3. 國家自然科學基金面上項目: 抗氧化劑修飾的絲素蛋白生物材料對細胞生長和功能的調控（項目主持）2012017年
4. 姑蘇領軍創業人才項目：絲素蛋白止血防粘連材料的開發和應用 （項目主持）2013-2017年
近五年發表的代表性論文和教材
2014-2017發表論文：
1. Wu J, Xie X, Zheng Z, Li G, Wang Y, Wang X*. Effect of pH on polyethylene glycol (PEG)-induced silk microsphere formation for drug delivery. Materials Science and Engineering: C Materials for Biological Applications. 2017 Nov 1;80:549-557.
2. Liu Y, Zheng Z, Guo S, Li G, Wang X*, Kaplan DL. DNA preservation in silk. Biomaterials Science. 2017 Jun 27;5(7):1279-1292.
3. Yang L, Zheng Z, Qian C, Wu J, Liu Y, Guo S, Li G, Liu M, Wang X, Kaplan DL. Curcumin-functionalized silk biomaterials for anti-aging utility. J Colloid Interface Sci. 2017;496:66-77 (SCI, IF: 3.368)
4. Luo T, Yang L, Wu J, Zheng Z, Li G, Wang X*, Kaplan DL. Stabilization of Natural Antioxidants by Silk Biomaterials. ACS Appl Mater Interfaces. 2016;8:13573-13582. doi: 10.1021/acsami.6b01636. Epub 2016 May 17. PMID: 27139741 (SCI, IF: 7.145; Field-Weighted Citation Impact: 0.83; cited number: 2)
5. Wu J, Zheng Z, Li G, Kaplan DL, Wang X*. Control of silk microsphere formation using polyethylene glycol (PEG). Acta Biomaterialia. 2016;39:156-168. doi: 10.1016/j.actbio.2016.05.019. Epub 2016 May 12. PMID: 27181879 (SCI, IF: 6.025; Field-Weighted Citation Impact: 1.98; cited number: 3)
6. Zheng Z, Guo S, Liu Y, Wu J, Li G, Liu M, Wang X*, Kaplan D. Lithium-free processing of silk fibroin. J Biomater Appl. 2016;31:450-463. doi: 10.1177/0885328216653259. Epub 2016 Jun 12. PMID: 27298185 (SCI, IF: 2.764; Field-Weighted Citation Impact: 0; cited number: 0)
7. Yu D，Sun C, Zheng Z, Wang X, Chen D, Wu H, Wang X*, Shi F. Inner ear delivery of dexamethasone using injectable silk-polyethylene glycol (PEG) hydrogel. Int J Pharm. 2016;503:229-237. doi: 10.1016/j.ijpharm.2016.02.048. Epub 2016 Mar 10. PMID: 26972377 (SCI, IF: 3.65; Field-Weighted Citation Impact: 5.03; cited number: 3)
8. Li G, Li F, Zheng Z, Luo T, Liu J, Wu J, Wang X*, Kaplan DL. Silk microfiber-reinforced silk composite scaffolds: fabrication, mechanical properties, and cytocompatibility. J Mater Sci. 2016;51:3025-3035 (SCI, IF: 2.302; Field-Weighted Citation Impact: 2.17; cited number: 2)
9. Wang Y, Liang M, Zheng Z, Shi L, Su B, Liu J, Kaplan DL, Zhang B, Wang X*. Adhesion Prevention after Laminectomy using Silk-polyethylene glycol (PEG) Hydrogels. Adv Healthc Mater. 2015;4:2120-2127 Aug 24. doi: 10.1002/adhm.201500392. [Epub ahead of print] PMID: 26386268 (SCI, IF: 5.76; Field-Weighted Citation Impact: 0.33; cited number: 1)
10. Lu D, Zheng Z, Guo S, Wang C, Kaplan DL, Wang X*. Binding quantum dots to silk biomaterials for optical sensing. J Sensors. 2015:819373 (SCI, IF: 0.712; Field-Weighted Citation Impact: 0.45; cited number: 1)
11. Zheng Z, Liu M, Guo S, Wu J, Lu D, Li G, Liu S, Wang X*, Kaplan DL. Incorporation of quantum dots in silk biomaterials for fluorescence imaging. J Mater Chem B Mater Biol Med. 2015;3:6509-6519. PMID: 26257913 PMCID: PMC4527682 (SCI, IF: 4.872; Field-Weighted Citation Impact: …; cited number: 3)
12. Li G, Liu J, Zheng Z, Wang X*, Kaplan DL. Structural Mimetic Silk Fiber-Reinforced Composite Scaffolds Using Multi-Angle Fibers. Macromol Biosci. 2015;15:1125-1133. doi: 10.1002/mabi.201400502. Epub 2015 Apr 16. PMID: 25879693 (SCI, IF: 3.85; Field-Weighted Citation Impact: 0.54; cited number: 2)
13. Li G, Li Y, Chen G, He J, Han Y, Wang X*, Kaplan DL. Silk-based biomaterials in biomedical textiles and fiber-based implants. Adv Healthc Mater. 2015;4:1134-1151 doi: 10.1002/adhm.201500002. Epub 2015 Mar 13. PMID: 25772248 PMCID: PMC4456268 (SCI, IF: 5.76; Field-Weighted Citation Impact: 1.3; cited number: 11)
14. Lovett ML, Wang X, Yucel T, York L, Keirstead M, Haggerty L, Kaplan DL. Silk hydrogels for sustained ocular delivery of anti-vascular endothelial growth factor (anti-VEGF) therapeutics. Eur J Pharm Biopharm. 2015;95:271-278 doi: 10.1016/j.ejpb.2014.12.029. Epub 2015 Jan 12. PMID: 25592326 (SCI, IF: 4.245; Field-Weighted Citation Impact: 3.07; cited number: 9)
15. Wang X*, Partlow B, Liu Jian, Zheng Z, Su Bo, Wang Y, Kaplan D. Injectable silk-polyethylene glycol hydrogels. Acta Biomaterialia. 2015;12:51-61 doi: 10.1016/j.actbio.2014.10.027. Epub 2014 Oct 25. PMID: 25449912 (SCI, IF: 6.025; Field-Weighted Citation Impact: 3.9; cited number: 15)
16. Zhou Shun, Huang Wenwen, Belton David J, Simmons Leo O, Perry Carole C, Wang X, Kaplan DL. Control of bioinspired silicification by genetically engineered fusion proteins: silk - silica binding peptides (SiBPs). Acta Biomaterialia. 2015;15:173-180 doi: 10.1016/j.actbio.2014.10.040. Epub 2014 Nov 4. PMID: 25462851 PMCID: PMC4331239 (SCI, IF: 6.025; Field-Weighted Citation Impact: 1.82; cited number: 7)
17. Li C, Luo T, Zheng Z, Murphy AR, Wang X*, Kaplan DL. Curcumin-functionalized silk materials for enhancing adipogenic differentiation of bone marrow-derived human mesenchymal stem cells. Acta Biomaterialia. 2015;11:222-232 doi: 10.1016/j.actbio.2014.08.009. Epub 2014 Aug 15. PMID: 25132274 PMCID: PMC4256115 (SCI, IF: 6.025; Field-Weighted Citation Impact: 2.08; cited number: 10)
18. Yin Y, Huang P, Li D, Han Z, Wei G, Zhou C, Wen J, Su B, Wang Y, Wang X*. Collagen nanofibers facilitated presynaptic maturation in differentiated neurons from spinal cord-derived neural stem cells through MAPK/ERK1/2- Synapsin I signaling pathway. Biomacromolecules. 2014;15:2449-2460 doi: 10.1021/bm500321h. Epub 2014 Jul 1. PMID: 24955924 (SCI, IF: 5.75; Field-Weighted Citation Impact: 1.18; cited number: 8)
19. Leng X, Liu B, Su B, Liang M, Shi L, Li S, Qu S, Fu X, Liu Y, Yao M, Wang Y, Wang X*, Kaplan DL. In Situ Ultrasound Imaging of Silk Hydrogel Degradation and Neovascularization. J Tissue Eng Regen Med. 2017;11:822-830; Med. doi: 10.1002/term.1981. Accession number: 25850825 doi: 10.1002/term.1981. Epub 2015 Apr 5. PMID: 25850825 (SCI, IF: 2.37; Field-Weighted Citation Impact: 0.74; cited number: 1)
20. Qing Liu, Shufa Zhou, Zeyu Zhao, Zhaozhu ZHENG, Gang Li, Xiaoqin Wang. SF/polyethylene Glycol nano-fibrous membranes loaded with Curcumin, Thermal Science 2017, 21(4), 21-27. (SCI, IF 0.95)
授權發明專利情況
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聯系方式
聯系電話：0512-65882725 E-Mail: wangxiaoqin@suda.edu.cn
